Interpreting genomic variants is one of the most time-consuming and complex tasks in clinical genomics. Each variant must be assessed for its clinical significance using established guidelines (where available), curated databases, and the latest...

VarSome Clinical Oncology Germline

Automated Germline and Somatic Classification

By Jason Armstrong on September 22, 2025

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VarSome Clinical is a CE IVDR-certified, HIPAA-compliant platform for interpreting NGS data. It supports analysis of genomes, exomes, and gene panels from individual samples, trios, families, or cohorts.

VarSome Clinical Oncology Germline

Germline and Somatic Pipelines

By Jason Armstrong on September 22, 2025

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VarSome Clinical offers two types of filtering: algorithmic filters, which run during analysis to prioritize variants, and dynamic filters, which give you flexible control over how results are viewed and explored.Together, they help reduce noise...

VarSome Clinical Oncology Germline

Algorithmic and Dynamic Filters

By Jason Armstrong on September 22, 2025

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VarSome Clinical is designed to process NGS data, from gene panels to whole genomes, and supports FASTQ or VCF files. To effectively use the platform, it's important to understand the data upload methods and the specific requirements for different...

VarSome Clinical

File Uploads - VarSome Clinical

By Jason Armstrong on September 22, 2025

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Each year, International Programmers’ Day is marked on the 256th day of the calendar. This number is chosen because 256 is both the total number of values an eight-bit byte can represent and the largest power of 2 below 365. Depending on the year,...

Community Technology Awareness Days

International Programmers' Day 2025

By Jason Armstrong on September 12, 2025

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Did you know you can search the entire VarSome knowledge base using plain text? Whether you’re investigating a specific gene, variant, condition, or concept, VarSome’s full text search helps you find relevant content quickly, without needing...

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Fast Answers with Full Text Search

By Jason Armstrong on August 22, 2025

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Tumor mutational burden (TMB) and Microsatellite Instability (MSI) are now established biomarkers guiding immunotherapy decisions across a growing list of solid tumors. This article outlines how TMB and MSI are defined and assessed in VarSome...

Platform Updates Technology VarSome Clinical Oncology

TMB & MSI Biomarkers

By Jason Armstrong on August 12, 2025

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Community VarSome.com VarSome.com Premium VarSome in Action

Liquid Biopsy in SCLC: Steps Toward Routine Clinical Use

By Xanthippi Papakonstanti on August 5, 2025

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Lausanne, Switzerland & Murcia, Spain, 30 July 2025 — Saphetor, the creators of the industry-leading VarSome suite of NGS bioinformatics tools, announces a new partnership with LongSeq, a Spanish biotechnology company specialized in advanced...

Press Releases VarSome Clinical News

Saphetor and LongSeq Partner to Expand Access to Advanced Long-Read Sequencing Diagnostics in Spain

By Carl Smith on July 30, 2025

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VarSome Clinical now lets you build report templates that match your laboratory's requirements.

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Custom Report Templates in VarSome Clinical

By Jason Armstrong on July 24, 2025

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Mapping cyber threats in sequencing, analysis, and reporting.

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Does Genomics Have A Security Problem?

By Jason Armstrong on June 5, 2025

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Wong M, Liew B, Hum M, Lee NY, Lee ASG. Benchmarking of variant calling software for whole-exome sequencing using gold standard datasets. Sci Rep. 2025;15(1):13697. doi:10.1038/s41598-025-97047-7

Community VarSome.com Research Brief News

Benchmarking Variant Calling Tools - Wong et al., 2025

By Jason Armstrong on May 13, 2025

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