In clinical genomics, you are often confronted with fragmented, siloed data sources in different formats and the constant challenge of bringing together disparate sets of evidence. To provide you with a comprehensive and integrated solution, we built VarSome's MolecularDB.

What is MolecularDB?

MolecularDB is VarSome’s proprietary data-integration engine. It draws together over 140 genomic data sources, our expert curation team, and user-contributed data to form a unified knowledge base. 

• We've integrated more than 140 data sources, meaning that you don’t need to visit each one manually, compare data formats, and bring them together to make an evidence-based decision. In VarSome Clinical, you can see sources like ClinVar, LOVD, OMIM®, and OncoKB™ with designated cards, get in silico predictions and SpliceVault data, and view your variants in context with our Sample Viewer and Region Browser. 
• MolecularDB drives VarSome’s downstream germline and somatic classification engines, based on ACMG/AMP rules and other published guidelines. With our classifiers, you see why each rule was and was not triggered, and clear explanations tell you the logic, so you can make an informed decision.
• The same engine supports whole genomes, exomes, and targeted panels, keeping annotations consistent across formats. It standardizes how variants are represented across reference builds, transcripts, HGVS descriptions, and caller outputs, so you spend less time resolving mismatches.

MolecularDB organises the evidence, and our tools and curated literature are built to support your assessment at each step. They streamline the review to help make sure your variant interpretation leads to an informed clinical decision.

Key Features at a Glance

With MolecularDB, VarSome brings together large-scale variant and gene-level data in a unified architecture. It supports both day-to-day interpretation workflows and larger-scale sequencing efforts.

For professionals facing the complexity of variant annotation, it offers a more streamlined, data-rich foundation. If you’re looking to reduce the burden of manual data curation and focus more on interpretation and impact, get in touch at sales@varsome.com to find out how we can help. 

Watch our KnowledgeHub session below, with Charles Chapple (Chief Scientific Officer) and Richard Meyer (Senior Developer), to find out more about data integration and our MolecularDB across the VarSome suite.

To see the full list of data sources integrated into VarSome’s MolecularDB, click here.

Or if you’d like to learn more about VarSome Clinical, click here.