--- title: Reclassification of VUS with VarSome description: Download our poster on reclassification of variants of uncertain significance through integrated data aggregation and community curation in VarSome. image: https://news.varsome.com/hubfs/Feat%20Image%20CCO%20Announcement1.png --- [![VarSome](https://news.varsome.com/hubfs/VarSome_February2020%20Theme/Images/logo.png)](https://varsome.com/) - Editions - [More about VarSome.com](https://varsome.com/varsome-editions/varsome/) - [More about VarSome Premium](https://varsome.com/varsome-editions/varsome-premium/) - [More about VarSome Clinical](https://varsome.com/varsome-editions/varsome-clinical/) - [Learn more about APIs](https://varsome.com/information/varsome-api-info/) - About - Resources - [Library](https://varsome.com/library/) - [Documentation](https://docs.varsome.com/) - [Query types](https://varsome.com/about/examples/) - [IVDR](https://landing.varsome.com/ivdr-whitepaper) - [Germline Classification](https://varsome.com/about/resources/acmg-implementation/) - [Somatic Classification](https://varsome.com/about/resources/amp-implementation/) - Partners - [Distributors](https://varsome.com/distributors/) - [Partners](https://varsome.com/partners/) - [Become a partner](https://landing.varsome.com/become-varsome-partner) - General - [The Company](https://saphetor.com/about/) - [Cite VarSome](https://varsome.com/about/varsome-citations/) - [Link to VarSome](https://varsome.com/how-do-i-create-link-varsome/) - [Contact](https://landing.varsome.com/contact) - [Community](https://varsome.com/community-contributions/) - [Blog](https://blog.varsome.com/) [Community](https://news.varsome.com/en/tag/community) [VarSome.com](https://news.varsome.com/en/tag/varsome-com) [Events](https://news.varsome.com/en/tag/events) # Reclassification of VUS with VarSome By [Lyndsey Fletcher](https://news.varsome.com/en/author/lyndsey-fletcher) on June, 19 2026 ### Categories - Select a Topic - [All](https://news.varsome.com/en) - [Partnerships](https://news.varsome.com/en/tag/partnerships) - [News](https://news.varsome.com/en/tag/news) - [Press Releases](https://news.varsome.com/en/tag/press-releases) - [VarSome Clinical](https://news.varsome.com/en/tag/varsome-clinical) - [Community](https://news.varsome.com/en/tag/community) - [Platform Updates](https://news.varsome.com/en/tag/platform-updates) - [VarSome.com](https://news.varsome.com/en/tag/varsome-com) - [Events](https://news.varsome.com/en/tag/events) - [Oncology](https://news.varsome.com/en/tag/oncology) - [Technology](https://news.varsome.com/en/tag/technology) - [VarSome.com Premium](https://news.varsome.com/en/tag/varsome-com-premium) - [Conferences](https://news.varsome.com/en/tag/conferences) - [Germline](https://news.varsome.com/en/tag/germline) - [VarSome in Action](https://news.varsome.com/en/tag/varsome-in-action) - [VarSome Team](https://news.varsome.com/en/tag/varsome-team) - [Awareness Days](https://news.varsome.com/en/tag/awareness-days) - [Whitepaper](https://news.varsome.com/en/tag/whitepaper) - [ACMG](https://news.varsome.com/en/tag/acmg) - [KnowledgeHub](https://news.varsome.com/en/tag/knowledgehub) - [Research Brief](https://news.varsome.com/en/tag/research-brief) - [VarSome API](https://news.varsome.com/en/tag/varsome-api) - [Application Note](https://news.varsome.com/en/tag/application-note) - [Community Q&A](https://news.varsome.com/en/tag/community-qa) - [VarSome Insights](https://news.varsome.com/en/tag/varsome-insights) ### Stay up to date ##### Search The Blog [Back to main Blog](https://news.varsome.com/en) [![](https://news.varsome.com/hs-fs/hubfs/1780856576699.png?height=100&name=1780856576699.png)](https://news.varsome.com/en/author/lyndsey-fletcher#blog-listing-section) ###### [Lyndsey Fletcher](https://news.varsome.com/en/author/lyndsey-fletcher#blog-listing-section) Content Marketer Variants of uncertain significance (VUS) are the most frequent outcome in germline genetic testing, with almost 30% of patients receiving only VUS results. This delays clinical decisions and forces manual review, complicating the interpretation of rare alleles. As genomic testing expands, rare variant discovery outpaces clinical curation. Because automated classifiers resolve only some VUS variants, scalable resolution requires systematic integration of diverse data sources. At ESHG 2026 in Gothenburg, we presented an analysis of the performance of VarSome's automated germline classifier (v13.15.2) which integrates evidence from 150+ genomic databases, literature, and community contributions in reclassifying ClinVar VUS variants. [Download the poster now](https://news.varsome.com/hubfs/Content/ESHG%20Poster%202026.pdf).   [Previous Post](https://news.varsome.com/en/overlap-with-known-structural-variants-in-varsome-clinical) [Next Post](https://news.varsome.com/en/world-population-day-2026) ### Stay up to date ## Latest News [See all blog posts](https://blog.varsome.com) ![](https://news.varsome.com/hubfs/VarSome_February2020%20Theme/Images/logo.png) - VarSome Suite - [VarSome.com](https://saphetor.com/varsome-editions/varsome/) - [VarSome Premium](https://saphetor.com/varsome-editions/varsome-premium/) - [VarSome Clinical](https://saphetor.com/varsome-editions/varsome-clinical/) - [VarSome API](https://varsome.com/information/varsome-api-info/) - System Status - [System Status](http://status.saphetor.com/) - Resources - [Query Examples](https://varsome.com/about/examples/) - [Documentation](https://docs.varsome.com/) - [Help Center](https://docs.varsome.com/en) - [Cite VarSome](https://news.varsome.com/en/cite-varsome-the-human-genomic-variant-search-engine) - The Company - [About Saphetor SA](https://saphetor.com/about/) - [News](https://blog.varsome.com) - [Distributors](https://landing.varsome.com/distributors) - [Contact](https://saphetor.com/contact/) - Legal - [Terms of Use](https://varsome.com/terms/) - [Privacy Policy](https://varsome.com/privacy/) VarSome Suite is brought to you by [Saphetor SA](https://saphetor.com). © 2024 Saphetor SA – All Rights Reserved.